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KMID : 0380420210450030103
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Journal of Prventive Veterinary Medicine
2021 Volume.45 No. 3 p.103 ~ p.108
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Effect of functional foods containing lactic acid bacteria on DSS-induced colitis
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Lee Hyun-A
So Sun-Ju
Choi In-Jeong
Kang So-Mi
Kim Ok-Jin
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Abstract
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Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the colon and rectum with intervals of acute exacerbation. Its etiology remains unknown, although recent studies suggest that pro-inflammatory cytokines initiate the inflammatory responses. In this study, we investigated the ameliorative effects of YB-21 (new product containining Lactobacillus plantarum, Barley Bran and Nymphaeaceae) in a dextran sulfate sodium (DSS)-induced colitis in mice. The experimental groups were divided into 6 groups (n = 10) of ICR mice: normal control(NC), DSS-treated(PC, positive control), DSS+latic-L-treated (3×107CFU/ml), DSS+latic-M-treated (3×109CFU/ml), DSS+latic-H-treated (3×1011CFU/ml), and DSS+YB-21-treated. Histological examinations indicated that YB-21 suppressed edema, mucosal damage, and the loss of crypts induced by DSS. Moreover, YB-21 reduced serum level expressions of, tumor necrosis factor-α (TNF-α). These results suggest that YB-21 has an anti-colitic effect by the suppression of intestinal inflammatory responses in DSS-induced colitis in mice.
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KEYWORD
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Inflammatory bowel disease(IBD), Dextran sodium sulfate(DSS), actobacillus plantarum, Barley Bran, Nymphaeaceae
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